H-gemcitabine: a new gemcitabine prodrug for treating cancer.

نویسندگان

  • Madhuri Dasari
  • Abhinav P Acharya
  • Dongin Kim
  • Seungjun Lee
  • Sungmun Lee
  • Jeanne Rhea
  • Ross Molinaro
  • Niren Murthy
چکیده

In this report, we present a new strategy for targeting chemotherapeutics to tumors, based on targeting extracellular DNA. A gemcitabine prodrug was synthesized, termed H-gemcitabine, which is composed of Hoechst conjugated to gemcitabine. H-gemcitabine has low toxicity because it is membrane-impermeable; however, it still has high tumor efficacy because of its ability to target gemcitabine to E-DNA in tumors. We demonstrate here that H-gemcitabine has a wider therapeutic window than free gemcitabine.

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عنوان ژورنال:
  • Bioconjugate chemistry

دوره 24 1  شماره 

صفحات  -

تاریخ انتشار 2013